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China Swine Industry ›› 2026, Vol. 21 ›› Issue (5): 98-106.doi: 10.16174/j.issn.1673-4645.2026.05.009

• Biosafety & Disease Prevention and Control • Previous Articles     Next Articles

Maintenance strategy and efficacy evaluation of Pseudorabies Virus (PRV) negative status in a large-scale swine farm

WU Guolin1,2, HONG Yang3, SHAO Lixiao4, JIANG Ping1, BAI Juan1*   

  1. 1College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; 2Anhui Antai Agricultural Development Co., Ltd., Xuancheng 242000, China; 3College of Animal Medicine, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, China; 4Weihai Wendeng District Animal Husbandry and Veterinary Service Development Center, Weihai 264400, China
  • Online:2026-11-13 Published:2026-10-25

Abstract: Taking a large-scale breeding pig farm in Anhui Province as the research object, this paper systematically elaborated on the construction logic, implementation path, and application effects of the comprehensive purification scheme for porcine pseudorabies in the farm. By establishing a “three-in-one” core purification technical system and path of “immunization-monitoring-elimination”, a targeted and refined vaccine immunization program was formulated and implemented, and continuous dynamic serological and etiological monitoring was carried out simultaneously to achieve precise prevention and control and gradual purification of the disease. The trial had been tracking and monitoring the test pig farm for 7 years. During this period, the farm had consistently tested negative for gE antibodies against porcine pseudorabies virus, while the positive rate for gB antibodies has remained above 90%. In 2024, the farm passed the national-level inspection for porcine pseudorabies eradication. After meeting the purification standards, the purified state of the farm was effectively maintained by strictly implementing the “all in and out” breeding mode, closed-herd breeding management, and comprehensive and rigorous biosecurity prevention and control measures. Practice had verified that the successful implementation of the porcine pseudorabies purification scheme in this farm, after six years of strict implementation, the production performance of the pig farm has seen significant improvement, the conception rate of reproductive sows has increased by an average of 1.00%, the farrowing rate has increased by an average of 1.02%, the survival rate of suckling piglets has increased by an average of 0.7%, the contribution rate of sows has increased by an average of 1.04%, the survival rate of finishing pigs has increased by an average of 0.43%, the feed-to-meat ratio of fattening pigs has decreased by an average of 0.04, and the animal protection cost has been reduced by an average of 12.16 yuan per head. And it had achieved a significant increase in the annual economic benefits of the pig farm. It was providing a scientifically feasible and replicable practical model for the purification of major animal diseases in large-scale pig farms in China.

Key words: pig, porcine pseudorabies, disease purification, precision immunization, dynamic monitoring, breeding benefits

CLC Number: 

  • S828
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