人工乳在哺乳仔猪生产中的应用研究进展

doi:10.16174/j.issn.1673-4645.2026.05.001

Abstract

Abstract: With the continuous improvement of reproductive performance in modern sow production, the relative insufficiency of sow milk supply has become an important factor limiting the growth, development, and survival of piglets. As a supplement to or substitute for sow milk, artificial milk is mainly used in early weaning and auxiliary feeding during lactation. This review summarized the effects of artificial milk on growth performance, intestinal health, and immune function in piglets, and on body condition in sows, and analyzed the regulatory effects of protein sources, functional additives, and feeding patterns on its efficacy. Current evidence indicated that artificial milk can improve weaning weight, survival rate, and within-litter uniformity of piglets in some extent, while reducing body condition loss in lactating sows. However, owing to differences from sow milk in bioactive components such as immunoglobulins, oligosaccharides, and growth factors, artificial milk cannot fully replace sow milk in regulating piglets's physiological development. Further studies are needed to optimize the formula composition and feeding strategies of artificial milk to enhance its nutritional supply and physiological regulatory functions.

Key words: artificial milk, piglets, growth performance, intestinal health, sow body condition, weaning weight

CLC Number:

S828

LIU Yan, LI Bin, WEI Tanghong, ZHOU Sishi, LI Zhenjiang, LIU Yunhan, LUO Hefeng, CHE Lianqiang. Advances in the application of artificial milk in suckling piglet production: a review[J].China Swine Industry, 2026, 21(5): 58-69.

References

[1] KNAP P W, KNOL E F, S?RENSEN A C, et al. Genetic and phenotypic time trends of litter size, piglet mortality, and birth weight in pigs[J]. Frontiers in Animal Science, 2023, 4: 1218175. [2] QUINIOU N, DAGORN J, GAUDRé D. Variation of piglets’ birth weight and consequences on subsequent performance[J]. Livestock Production Science, 2002, 78(1): 63-70. [3] QUESNEL H, FARMER C, DEVILLERS N. Colostrum intake: influence on piglet performance and factors of variation[J]. Livestock Science, 2012, 146(2/3): 105-114. [4] OBERMIER D R, HOWARD J T, GRAY K A, et al. The impact of functional teat number on reproductive throughput in swine[J]. Translational Animal Science, 2023, 7(1): txad100. [5] KOBEK-KJELDAGER C, MOUSTSEN V A, THEIL P K, et al. Effect of litter size, milk replacer and housing on production results of hyper-prolific sows[J]. Animal, 2020, 14(4): 824-833. [6] NOVOTNI-DANKó G, BALOGH P, HUZSVAI L, et al. Effect of feeding liquid milk supplement on litter performances and on sow back-fat thickness change during the suckling period[J]. Archives Animal Breeding, 2015, 58(1): 229-235. [7] ZHANG S H, CHEN F, ZHANG Y Z, et al. Recent progress of porcine milk components and mammary gland function[J]. Journal of Animal Science and Biotechnology, 2018, 9(1): 77. [8] ZHANG Y W, LIU S Y, ZHOU Q, et al. Impact of replacing sow milk with milk replacer on growth performance, intestinal development, bacterial profile and muscular maturation in neonatal and nursery piglets[J]. Frontiers in Veterinary Science, 2025, 12: 1565039. [9] VERGAUWEN H, DEGROOTE J, PRIMS S, et al. Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets[J]. Journal of Animal Science and Biotechnology, 2017, 8(1): 30. [10] HOJGAARD C K, BRUUN T S, THEIL P K. Impact of milk and nutrient intake of piglets and sow milk composition on piglet growth and body composition at weaning[J]. Journal of Animal Science, 2020, 98(3): skaa060. [11] NUNTAPAITOON M. Colostrum and milk in sow[J]. Milk Protein-New Research Approaches, 2022, 1-21. [12] THEIL P K, HURLEY W L. The protein component of sow colostrum and milk[M]. Milk Proteins - From Structure to Biological Properties and Health Aspects, 2016: 183-198. [13] LE DIVIDICH J, ROOKE J A, HERPIN P. Nutritional and immunological importance of colostrum for the new-born pig[J]. The Journal of Agricultural Science, 2005, 143(6): 469-485. [14] MEI J, ZHANG Y, WANG T, et al. Oral ingestion of colostrum alters intestinal transforming growth factor-beta receptor intensity in newborn pigs[J]. Livestock Science, 2006, 105(1/2/3): 214-222. [15] LUISE D, POLIMENI B, TREVISI P. A systematic review of the efficacy of complementary colostrum, milk, and oral nutritional and dietary solutions on the health, growth, and gut health of suckling piglets[J]. Journal of Animal Science, 2026, 104: skag095. [16] TANG C, LIU Z J, LU L, et al. The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets[J]. BMC Genomics, 2025, 26(1): 732. [17] OLIVER W T, MATHEWS S A, Phillips O, et al. Efficacy of partially hydrolyzed corn syrup solids as a replacement for lactose in manufactured liquid diets for neonatal pigs1[J]. Journal of Animal Science, 2002, 80(1): 143-153. [18] AMDI C, PEDERSEN M L M, LARSEN C, et al. Suckling induces differential gut enzyme activity and body composition compared to feeding milk replacer in piglets[J]. Animals, 2022, 12(22): 3112. [19] POULSEN A R, DE JONGE N, SUGIHARTO S, et al. The microbial community of the gut differs between piglets fed sow milk, milk replacer or bovine colostrum[J]. British Journal of Nutrition, 2017, 117(7): 964-978. [20] 辛怀璐, 蒋俊劼, 陈代文, 等. 饲喂人工乳对14日龄断奶仔猪生长性能、肠道抗氧化能力及屏障功能的影响[J]. 动物营养学报, 2020, 32(3): 1109-1117. XIN H L, JIANG J J, CHEN D W, et al. Effects of feeding artificial milk on growth performance, intestinal antioxidant capacity and barrier function of piglets weaning at 14 days of age[J]. Chinese Journal of Animal Nutrition, 2020, 32(3): 1109-1117. [21] DEVILLERS N, LESSARD M. New concepts related to the importance of colostrum for modern pig production[C].//Proceedings of the 43rd Eastern Nutrition Conference of the Animal Nutrition Association of Canada, 2007: 125-148. [22] JENSEN A R, ELNIF J, SANGILD P T, et al. Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent[J]. The Journal of Nutrition, 2001, 131(12): 3259-3265. [23] QUESNEL H, FARMER C, THEIL P K. Colostrum and milk production[M]//The gestating and lactating sow. The Netherlands: Wageningen Academic Publishers, 2015: 173-192. [24] DONG L I, ZHONG X, HE J T, et al. Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets[J]. Clinical Nutrition, 2016, 35(2): 399-407. [25] SAMPATH V, SONG J H, JEONG J, et al. Nourishing neonatal piglets with synthetic milk and Lactobacillus sp. at birth highly modifies the gut microbial communities at the post-weaning stage[J]. Frontiers in Microbiology, 2022, 13: 1044256. [26] CHEM V, MUN H S, AMPODE K M B, et al. Milk Supplementation: effect on piglets performance, feeding behavior and sows physiological condition during the lactation period[J]. Journal of Animal Behaviour and Biometeorology, 2023, 11(1): 2023007. [27] 张斐然, 邓为, 向丰禺, 等. 人工乳用小麦水解蛋白对仔猪生长性能、代谢、免疫和抗氧化的影响[J]. 畜牧兽医学报, 2026, 57(2): 839-847. ZHANG F R, DENG W, XIANG F Y, et al. Effects of using hydrolyzed wheat gluten in artificial milks on the growth performance, nutrient metabolism, immune function and antioxidant capacity of piglets[J]. Acta Veterinaria et Zootechnica Sinica, 2026, 57(2): 839-847. [ [28] GY?RI Z, BALOGH P, HUZSVAI L, et al. Effect of supplemental pig milk replacer on piglet weight gain and sow backfat thickness[J]. Acta Agraria Debreceniensis, 2015(65): 43-47. [29] PUSTAL J, TRAULSEN I, PREI?LER R, et al. Providing supplementary, artificial milk for large litters during lactation: effects on performance and health of sows and piglets: a case study[J]. Porcine Health Management, 2015, 1(1): 13. [30] CABRERA R A, BOYD R D, JUNGST S B, et al. Impact of lactation length and piglet weaning weight on long-term growth and viability of progeny[J]. Journal of Animal Science, 2010, 88(7): 2265-2276. [31] PARK B C, HA D M, PARK M J, et al. Effects of milk replacer and starter diet provided as creep feed for suckling pigs on pre- and post- weaning growth[J]. Nihon Chikusan Gakkaiho, 2014, 85(9): 872-878. [32] WOLTER B F, ELLIS M, CORRIGAN B P, et al. The effect of birth weight and feeding of supplemental milk replacer to piglets during lactation on preweaning and postweaning growth performance and carcass characteristics[J]. Journal of Animal Science, 2002, 80(2): 301-308. [33] VAN TICHELEN K, PRIMS S, AYUSO M, et al. The effect of drenching (very) low birth weight piglets with a dense, concentrated milk replacer at farms with differing farrowing management[J]. Animals, 2022, 13(1): 63. [34] VAN OOSTRUM M, LAMMERS A, MOLIST F. Providing artificial milk before and after weaning improves postweaning piglet performance[J]. Journal of Animal Science, 2016, 94(suppl_3): 429-432. [35] CORREA F, LUISE D, NEGRINI C, et al. Effect of two milk supplements and two ways of administration on growth performance, welfare and fecal microbial ecology of suckling piglets[J]. Frontiers in Veterinary Science, 2023, 10: 1050414. [36] PRIMS S, PINTENS N, VERGAUWEN H, et al. Effect of artificial rearing of piglets on the volume densities of M cells in the tonsils of the soft palate and ileal Peyer’s patches[J]. Veterinary Immunology and Immunopathology, 2017, 184: 1-7. [37] DE VOS M, HUYGELEN V, VAN RAEMDONCK G, et al. Supplementing formula-fed piglets with a low molecular weight fraction of bovine colostrum whey results in an improved intestinal barrier, 2[J]. Journal of Animal Science, 2014, 92(8): 3491-3501. [38] TAN B, LI X G, KONG X, et al. Dietary l-arginine supplementation enhances the immune status in early-weaned piglets[J]. Amino Acids, 2009, 37(2): 323-331. [39] MADSEN J G, MUELLER S, KREUZER M, et al. Milk replacers supplemented with either L-arginine or L-carnitine potentially improve muscle maturation of early reared low birth weight piglets from hyperprolific sows[J]. Animal, 2018, 12(1): 43-53. [40] JACOBI S K, MOESER A J, CORL B A, et al. Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigs[J]. The Journal of Nutrition, 2012, 142(7): 1266-1271. [41] WAN H F, ZHU J T, SU G Q, et al. Dietary supplementation with β-hydroxy-β-methylbutyrate calcium during the early postnatal period accelerates skeletal muscle fibre growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets[J]. British Journal of Nutrition, 2016, 115(8): 1360-1369. [42] LI M, MONACO M H, WANG M, et al. Human milk oligosaccharides shorten rotavirus-induced diarrhea and modulate piglet mucosal immunity and colonic microbiota[J]. The ISME Journal, 2014, 8(8): 1609-1620. [43] COMSTOCK S S, LI M, WANG M, et al. Dietary human milk oligosaccharides but not prebiotic oligosaccharides increase circulating natural killer cell and mesenteric lymph node memory T cell populations in noninfected and rotavirus-infected neonatal piglets 1 2[J]. The Journal of Nutrition, 2017, 147(6): 1041-1047. [44] MILLER Y J, COLLINS A M, SMITS R J, et al. Providing supplemental milk to piglets preweaning improves the growth but not survival of gilt progeny compared with sow progeny[J]. Journal of Animal Science, 2012, 90(13): 5078-5085. [45] HAN Q, ZHANG X, NIAN H, et al. Artificial rearing alters intestinal microbiota and induces inflammatory response in piglets[J]. Frontiers in Microbiology, 2022, 13: 1002738. [46] HAO Y, XING M, GU X. Research progress on oxidative stress and its nutritional regulation strategies in pigs[J]. Animals, 2021, 11(5): 1384. [47] BORTOLOZZO F P, ZANIN G P, ULGUIM R D R, et al. Managing reproduction in hyperprolific sow herds[J]. Animals, 2023, 13(11): 1842. [48] DOURMAD J Y, LE VELLY V, GOURDINE J L, et al. Effect of ambient temperature in lactating sows, a meta-analysis and simulation approach in the context of climate change[J]. Animal-Open Space, 2022, 1(1): 100025. [49] LO VERSO L, MATTE J J, LAPOINTE J, et al. Impact of birth weight and neonatal nutritional interventions with micronutrients and bovine colostrum on the development of piglet immune response during the peri-weaning period[J]. Veterinary Immunology and Immunopathology, 2020, 226: 110072. [50] BLAVI L, SOLA-ORIOL D, LLONCH P, et al. Management and feeding strategies in early life to increase piglet performance and welfare around weaning: a review[J]. Animals, 2021, 11(2): 302.

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Advances in the application of artificial milk in suckling piglet production: a review

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