基于GWAS挖掘大白猪初生重和乳头数的候选基因

doi:10.16174/j.issn.1673-4645.2026.05.006

Abstract

Abstract: Birth weight and teat number directly affect piglet survival rate and production efficiency. In this study, genome-wide association study (GWAS) was performed to identify candidate genes associated with birth weight and teat number traits in Large White pigs, providing a theoretical basis for molecular breeding. A total of 1 244 Large white pigs were genotyped using a porcine 80K functional SNP chip, and after quality control, 147 973 SNPs were retained for subsequent analysis. GWAS was conducted for birth weight, left teat number, right teat number and total teat number using the General linear model (GLM), Mixed linear model (MLM) and Fixed and random model Circulating Probability Unification (FarmCPU) in the rMVP package. The results showed that the heritabilities estimates for birth weight, left teat number, right teat number and total teat number were 0.373, 0.227, 0.189 and 0.236 respectively. By integrating the results from the three models, candidate genes affecting birth weight included CADM2, KDM5B, SLC36A 1 and so on, while candidate genes affecting teat number included ZMYND8, DSCAML1, EYA 2, and so on . GO functional enrichment analysis indicated that candidate genes for birth weight were significantly enriched in biological processes such as neuronal development and morphogenesis, whereas candidate genes for teat number were significantly enriched in biological processes such as neural development and steroid hormone signal transduction.

Key words: Large white pigs, GWAS, birth weight, teat number, candidate genes, gene chip

CLC Number:

S828

LIN Jian, CHEN Xinyue, FENG Yue, XU Zhong, GU Yiren. Identification of candidate genes for birth weight and teat number in large white pigs based on GWAS[J].China Swine Industry, 2026, 21(5): 3-10.

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Identification of candidate genes for birth weight and teat number in large white pigs based on GWAS

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