中国猪业 ›› 2026, Vol. 21 ›› Issue (5): 98-106.doi: 10.16174/j.issn.1673-4645.2026.05.009
吴国林1,2,洪阳3,邵丽晓4,姜平1,白娟1*
WU Guolin1,2, HONG Yang3, SHAO Lixiao4, JIANG Ping1, BAI Juan1*
摘要: 本文以安徽省某规模化种猪场为研究对象,系统阐述了猪伪狂犬病综合净化方案的构建逻辑、实施路径及应用效果。通过确立“免疫—监测—淘汰”三位一体的核心净化技术体系,制定并执行精准化疫苗免疫程序,同步开展持续动态的血清学与病原学监测,实现对疫病的精准防控与逐步净化。试验跟踪监测试验猪场7年,7年间该猪场一直是猪伪狂犬病病毒gE抗体阴性,gB抗体阳性率持续高于90%,该猪场于2024年通过国家级猪伪狂犬病净化审查。猪场在达到净化标准后,继续严格执行全进全出养殖模式、闭群繁育管理及全方位生物安全防控措施,有效维持了猪场净化状态。研究发现,该净化方案成功落地后,经过6年的严格执行,猪场生产成绩明显提升,能繁母猪受胎率平均提升1.00%、分娩率平均提升1.02%、哺乳仔猪成活率平均提升0.7%、母猪贡献率平均提升1.04%、育成猪成活率平均提升0.43%、育肥猪料肉比平均下降0.04、动保费用平均降低12.16元/头,且实现了猪场年均经济效益的大幅增长,为我国规模化猪场重大动物疫病的净化及维持工作提供了科学可行、可复制推广的实践范例。
中图分类号: S828;S852.65
| [1] ZHENG H H, FU P F, CHEN H Y, et al. Pseudorabies virus: from pathogenesis to prevention strategies[J]. Viruses, 2022, 14(8): 1638. [2] BO Z Y, LI X D. A review of pseudorabies virus variants: genomics, vaccination, transmission, and zoonotic potential[J]. Viruses, 2022, 14(5): 1003. [3] 李春华, 王英, 蒋凤英, 等. 猪伪狂犬病研究进展[J]. 动物医学进展, 2008(3): 68-72. LI C H, WANG Y, JIANG F Y, et al. Progress on porcine pseudorabies [J]. Progress in Veterinary Medicine, 2008(3): 68-72. [4] TAN L, YAO J, YANG Y D, et al. Current status and challenge of pseudorabies virus infection in China[J]. Virologica Sinica, 2021, 36(4): 588-607. [5] 华利忠, 刘剑锋, 冯志新, 等. 猪伪狂犬病病毒新流行变异毒株的研究进展[J]. 江苏农业学报, 2017, 33(2): 476-480. HUA L Z, LIU J F, FENG Z X, et al. Progress in novel pseudorabies virus variants prevalent in China[J]. Jiangsu Journal of Agricultural Sciences, 2017, 33(2): 476-480. [6] SEHL J, TEIFKE J P. Comparative pathology of pseudorabies in different naturally and experimentally infected species-a review[J]. Pathogens, 2020, 9(8): 633. [7] 陈叶, 付新亮, 粟硕, 等. 猪伪狂犬的防控策略和净化[J]. 广东饲料, 2014, 23(6): 46-48. CHEN Y, FU X L, SU S, et al. Prevention and control strategy and purification of pseudorabies in pigs[J]. Guangdong Feed, 2014, 23(6): 46-48. [8] ZHUANG L L, GONG J S, SHEN J Y, et al. Advances in molecular epidemiology and detection methods of pseudorabies virus[J]. Discover Nano, 2025, 20(1): 45. [9] 何启盖, 童光志, 杨汉春, 等. 猪伪狂犬病流行病学特征、净化技术及其应用示范[J]. 中国畜牧杂志, 2015, 51(24): 68-74. HE Q G, TONG G Z, YANG H C, et al. Epidemiological characterization of swine pseudorabies, eradication technologies and application[J]. Chinese Journal of Animal Science, 2015, 51(24): 68-74. [10] ZHOU M, ABID M, CAO S N, et al. Progress of research into novel drugs and potential drug targets against porcine pseudorabies virus[J]. Viruses, 2022, 14(8): 1753. [11] YE N, FENG W, FU T T, et al. Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus[J]. Veterinary Research, 2023, 54(1): 39. [12] 曹洁, 罗红彬. 抗伪狂犬病病毒药物筛选研究进展[J]. 动物医学进展, 2024, 45(7): 107-113. CAO J, LUO H B. Progress on anti-PRV drug screening[J]. Progress in Veterinary Medicine, 2024, 45(7): 107-113. [13] LIU Q Y, KUANG Y, LI Y F, et al. The epidemiology and variation in pseudorabies virus: a continuing challenge to pigs and humans[J]. Viruses, 2022, 14(7): 1463. [14] 史岩, 朱连德. 猪伪狂犬病防控与净化[J]. 中国动物保健, 2009, 11(9): 63-66. SHI Y, ZHU L D. Prevention, control, and eradication of porcine pseudorabies[J]. China Animal Health, 2009, 11(9): 63-66. [15] 刘准, 臧传佼, 易新健, 等. 山东省某猪场猪伪狂犬病的诊断鉴定及防治措施[J]. 畜牧兽医杂志, 2017, 36(2): 104-107. LIU Z, ZANG C J, YI X J, et al. Diagnostic identification and precention measures of pseudorabies virus from pig farm in Shandong province[J]. Journal of Animal Science and Veterinary Medicine, 2017, 36(2): 104-107. [16] 洪天旗, 陈培华, 陈彬, 等. 猪伪狂犬病的诊断、防控及净化[J]. 畜牧与兽医, 2018, 50(3): 131-136. HONG T Q, CHEN P H, CHEN B, et al. Diagnosis, control and eradication of pseudorabies in pigs[J]. Animal Husbandry & Veterinary Medicine, 2018, 50(3): 131-136. [17] 冯伟, 付畑畑, 汪忠荣, 等. 猪伪狂犬病疫苗研究进展[J]. 动物医学进展, 2025, 46(2): 92-97. FENG W, FU T T, WANG Z R, et al. Progress on porcine pseudorabies vaccine[J]. Progress in Veterinary Medicine, 2025, 46(2): 92-97. [18] 郭振华, 原黎伟. 后非洲猪瘟时代我国猪伪狂犬病和猪瘟防控净化策略[J]. 中国猪业, 2023, 18(4): 82-85, 89. GUO Z H, YUAN L W. Prevention and control strategies of pseudorabies and swine fever in China in the post-African swine fever era[J]. China Swine Industry, 2023, 18(4): 82-85, 89. [19] 余春明, 邓柏林, 郑雪莹, 等. 猪伪狂犬病防控技术研究进展[J]. 猪业科学, 2022, 39(2): 108-109. YU C M, DENG B L, ZHENG X Y, et al. Research progress on prevention and control technology of porcine pseudorabies[J]. Swine Industry Science, 2022, 39(2): 108-109. [20] 董林, 谢金文, 刘吉山, 等. 5种猪场常用消毒剂对PCV2和PRV的消毒效果评价[J]. 中国动物检疫, 2024, 41(6): 107-114. DONG L, XIE J W, LIU J S, et al. Evaluation on the disinfection effects of 5 disinfectants commonly used by swine farms against PCV2 and PRV[J]. China Animal Health Inspection, 2024, 41(6): 107-114. [21] 康冬柳, 曾桂根, 朱淑琴, 等. 仓箱式堆肥发酵法处理病死猪试点情况初报[J]. 江西畜牧兽医杂志, 2014(6): 22-23. KANG D L, ZENG G G, ZHU S Q, et al. Preliminary report on the pilot project of treating dead pigs with compost fermentation in bin-type composting[J]. Jiangxi Journal of Animal Husbandry & Veterinary Medicine, 2014(6): 22-23. [22] 刘玉梅, 张锐, 刁新育, 等. 规模养殖、疫病净化与企业效益分析——基于猪伪狂犬病净化的调查研究[J]. 中国兽医杂志, 2017, 53(7): 106-110. LIU Y M, ZHANG R, DIAO X Y, et al. Large-scale breeding, disease eradication, and enterprise benefit analysis: an investigation based on the eradication of porcine pseudorabies[J]. Chinese Journal of Veterinary Medicine, 2017, 53(7): 106-110. [23] 郭镇洋, 田志军, 彭金美. 中国猪伪狂犬病的流行及防控[J]. 中国科学: 生命科学, 2023, 53(12): 1780-1793. GUO Z Y, TIAN Z J, PENG J M. Epidemic prevention and control of porcine pseudorabies in China[J]. Scientia Sinica (Vitae), 2023, 53(12): 1780-1793. [24] 牛建强, 蓝天, 罗旭芳, 等. 规模化猪场伪狂犬病的控制和净化[J]. 中国畜牧兽医, 2006, 33(7): 58-59. NIU J Q, LAN T, LUO X F, et al. Control and purification of pseudorabies in large-scale pig farms[J]. China Animal Husbandry & Veterinary Medicine, 2006, 33(7): 58-59. [25] SUN Y, LUO Y Z, WANG C H, et al. Control of swine pseudorabies in China: opportunities and limitations[J]. Veterinary Microbiology, 2016, 183: 119-124. [26] PEREZ A M, CLAVIJO A, RODRIGUEZ-HERRERA S, et al. Oral fluid PCR monitoring for Aujeszky's disease virus detection in a swine farm[J]. Revista Argentina de Microbiologia?, 2026, 58(1): 18-22. [27] 徐苏标. 猪伪狂犬病的防控策略及净化方案[J]. 国外畜牧学(猪与禽), 2016, 36(6): 19-22. XU S B. Prevention and control strategies and eradication plan for porcine pseudorabies[J]. Animal Science Abroad(Pigs and Poultry), 2016, 36(6): 19-22. [28] 靳冬, 曹伟伟, 赵胜杰. 2020—2024年河南省猪群伪狂犬gE抗体监测分析[J]. 上海畜牧兽医通讯, 2025(5): 22-25. JIN D, CAO W W, ZHAO S J. Surveillance and analysis of pseudorabies gE antibody in pig herds in Henan province from 2020 to 2024[J]. Shanghai Journal of Animal Husbandry and Veterinary Medicine, 2025(5): 22-25. [29] JIANG L Y, CHENG J L, PAN H, et al. Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China[J]. BMC Genomics, 2024, 25(1): 752. [30] CHENG X J, CHENG N, YANG C, et al. Emergence and etiological characteristics of novel genotype Ⅱ pseudorabies virus variant with high pathogenicity in Tianjin, China[J]. Microbial Pathogenesis, 2024, 197: 107061. [31] NA L, SUN Y, QIU W Y, et al. Development of a competitive ELISA for detecting antibodies against pseudorabies virus glycoprotein D[J]. Transboundary and Emerging Diseases, 2025, 2025: 1263531. [32] GAO W H, ZHANG M, ZHU Z B. The prevalence of pseudorabies virus in China from 2010 to 2024: a systematic review and meta-analysis[J]. BMC Veterinary Research, 2025, 21(1): 513. [33] 袁红, 练斯南, 张衡, 等. 新型猪伪狂犬病流行情况及净化措施[J]. 中国动物检疫, 2016, 33(3): 58-62. YUAN H, LIAN S N, ZHANG H, et al. The epidemic situation and purifi cation measures of the new swine pseudorabies[J]. China Animal Health Inspection, 2016, 33(3): 58-62. [34] 李达, 马萍, 汤德元, 等. 规模化猪场猪瘟和伪狂大病的净化方案[J]. 畜牧与兽医, 2015, 47(7): 119-123. LI D, MA P, TANG D Y, et al. Purification scheme of swine fever and pseudorabies in large-scale pig farms[J]. Animal Husbandry & Veterinary Medicine, 2015, 47(7): 119-123. [35] LU J J, YUAN W Z, ZHU Y P, et al. Latent pseudorabies virus infection in medulla oblongata from quarantined pigs[J]. Transboundary and Emerging Diseases, 2021, 68(2): 543-551. [36] 邵金龙. 对猪伪狂犬病的再认识及防控技术[J]. 福建畜牧兽医, 2025, 47(1): 41-43. SHAO J L. Re-recognition and prevention and control techniques for porcine pseudorabies[J]. Fujian Journal of Animal Husbandry and Veterinary Medicine, 2025, 47(1): 41-43. [37] 洪枫, 孟沛, 魏旭文. 一例规模猪场猪伪狂犬病净化及效益评估[J]. 猪业科学, 2024, 41(1): 60-61. HONG F, MENG P, WEI X W. Purification and benefit evaluation of pseudorabies in a large-scale pig farm[J]. Swine Industry Science, 2024, 41(1): 60-61. [38] 王军, 丁维民. 安徽某规模猪场猪伪狂犬病的净化实践与探索[J]. 养殖与饲料, 2022, 21(10): 95-98. WANG J, DING W M. Purification practice and exploration of porcine pseudorabies in a large-scale pig farm in Anhui province[J]. Animals Breeding and Feed, 2022, 21(10): 95-98. |
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