China Swine Industry ›› 2025, Vol. 20 ›› Issue (2): 15-22.doi: 10.16174/j.issn.1673-4645.2025.02.002

• Special Report • Previous Articles     Next Articles

  

  • Online:2025-04-30 Published:2025-04-25

Abstract: Gene editing technology had demonstrated significant potential in the genetic improvement of pigs and biomedical research. Gene-edited pigs exhibited good production traits and disease resistance, which could increase breeding income. Due to their closer resemblance to humans in anatomical structure, metabolism, and physiological-biochemical characteristics compared to rodents, pigs served as ideal disease models and xenotransplantation organ donors. However, gene-edited pigs also faced multiple challenges, including the need to improve the efficiency and accuracy of gene editing, as well as addressing off-target effects that might lead to unintended genetic alterations. Additionally, divergent regulatory policies across regions pose obstacled to the industrialization and commercialization of gene-edited pigs. A comprehensive understanding of the current status and challenges of gene-edited pigs would facilitate their rational development in scientific research and practical applications.

Key words: pig, gene editing, xenotransplantation, CRISPR/Cas9, genetic improvement, metabolism, physiology

CLC Number: 

  • S828
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