中国猪业 ›› 2018, Vol. 13 ›› Issue (2): 52-54.doi: 10.1111/1673-4645-2018-02-0052
PRRSV非结构蛋白抑制宿主先天性免疫的分子机制
徐善之(
),田质高,陈飞
- 张家港出入境检验检疫局,江苏张家港 215600
摘要：
自20世纪80年代被发现以来,猪繁殖和呼吸障碍综合征（PRRS）给全球养猪业带来了巨大的经济损失,PRRS的防控也成为了世界性难题。先天性免疫系统在宿主抵抗病毒感染的过程中发挥着重要作用,然而猪繁殖和呼吸障碍综合征病毒（PRRSV）采取了多种策略干扰了该系统中的信号转导通路,引起了宿主明显的免疫抑制现象。总结了PRRSV利用其非结构蛋白（Nsp1、Nsp2、Nsp4、Nsp11）逃逸宿主先天免疫的机制,介绍了PRRSV致病、引起免疫抑制的机理,以期为PRRSV的防控及新型疫苗与药物的研发提供新的思路和方法。
中图分类号:
- S852.65
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ISSN 1673-4645
CN 11-5435/S
主管：中华人民共和国农业农村部
主办：中国农业科学院农业信息研究所
CN 11-5435/S
主管：中华人民共和国农业农村部
主办：中国农业科学院农业信息研究所
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