中国猪业 ›› 2024, Vol. 19 ›› Issue (2): 59-66.doi: 10.16174/j.issn.1673-4645.2024.02.007

• 生物安全与疫病防控 • 上一篇    

我国猪蓝耳病NADC34-like毒株的流行病学及致病性研究进展

李金海,李兴玉   

  • 出版日期:2024-04-25 发布日期:2024-04-25

  • Online:2024-04-25 Published:2024-04-25

摘要: 猪繁殖与呼吸综合征(PRRS)又称猪蓝耳病,在我国广泛流行,常见流行毒株种类很多。我国自2017 年首次检测到NADC34-like 毒株以来,该毒株的传播呈逐年上升趋势,给猪场蓝耳病防控提出了新的挑战。本文综述了我国不同地区猪蓝耳病NADC34-like 毒株的流行情况和分离毒株的致病性研究,以期为当前猪场蓝耳病的防控提供参考。

关键词: 生猪;猪蓝耳病;繁殖与呼吸障碍综合征;流行现状;致病性研究

中图分类号:  S828;S852.65

[1] 杜兴乾. 规模化猪场PRRSV血清驯化对后备母猪生产性能的影响[D]. 杨凌: 西北农林科技大学, 2021. DU XQ. Effect of PRRSV serum domestication on production performance of sows in largescale pig farms[D]. Yangling: Northwest A&F University, 2021. [2] 孟利佳. 类NADC30株致猪繁殖与呼吸综合征诊断与防治的研究[D]. 保定: 河北农业大学, 2018. MENG LJ. Study on diagnosis and prevention of NADC30-like porcine reproductive and respiratory syndrome[D]. Baoding: Hebei Agricultural University, 2018. [3] 黄明广. 猪蓝耳病的诊断与防治[J]. 中国动物保健, 2022, 24(12):17-18. HUANG MG. Diagnosis and prevention of PRRS[J]. China Animal Health, 2022, 24(12):17-18. [4] 许艳华, 李富强, 董志民, 等. 猪蓝耳病病毒与副猪嗜血杆菌及猪链球菌混合感染的诊治[J]. 天津农业科学, 2022, 28(S1):22-27. XU YH, LI FQ, DONG ZM, et al. Diagnosis and treatment of the co-infection of porcine reproductive and respiratory syndrome virus, haemophilus parasuis and streptococcus suis[J]. Tianjin Agricultural Sciences, 2022, 28(S1):22-27. [5] 张垚垚, 李国, 陆阔, 等. 一例猪蓝耳病、伪狂犬病、猪链球菌病和副猪嗜血杆菌病混合感染的诊治[J]. 养猪, 2022(2):95-99. ZHANG YY, LI G, LU K, et al. Diagnosis and treatment of a case of mixed infection of PRRS,PR, SS and HPS[J]. Swine Production, 2022(2):95-99. [6] 孙琪, 许浒, 李超, 等. 欧洲型和美洲型PRRSV的最新分类及其差异的研究进展[J]. 中国预防兽医学报, 2022, 44(9):1006-1013. SUN Q, XU H, LI C, et al. Research progress on the latest classification of European and North American PRRSV and their differences[J]. Chinese Journal of Preventive Veterinary Medicine, 2022, 44(9):1006-1013. [7] VAN GEELEN AM, ANDERSON TK, LAGER KM,et al. Porcine reproductive and respiratory disease virus: Evolution and recombination yields distinct ORF5 RFLP 1-7-4 viruses with individual pathogenicity[J]. Virology, 2017, 513(1):168-179. [8] MERCY R, FERNANDO B, DENNIS B, et al. Detection of porcine reproductive and respiratory syndrome virus (PRRSV) 1-7-4-type strains in Peru[J]. Transboundary and Emerging Diseases, 2019, 66(3):1107-1113. [9] KIM SC, MOON SH, JEONG CG, et al. Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea[J]. Virology Journal, 2022, 19(1):1-13. [10] SHI M, LAM T, HON CC, et al. Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses[J]. Journal of Virology, 2010, 84(17):8700-8711. [11] 刘建奎, 徐叶, 刘辰, 等. 基于全基因组分析2017―2021年福建省猪繁殖与呼吸综合征病毒基因组特征[J]. 畜牧兽医学报, 2023, 54(4):1579-1589. LIU JK, XU Y, LIU C, et al. Genomic characteristics of porcine reproductive and respiratory syndrome virus in Fujian province from 2017 to 2021 based on whole genome[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4):1579-1589. [12] ZHAO HZ, WANG FX, HAN XY, et al. Recent advances in the study of NADC34-like porcine reproductive and respiratory syndrome virus in China[J]. Frontiers in Microbiology, 2022, 13. doi: 10.3389/FMICB.2022.950402. [13] WESLEY RD, MENGELING WL, LAGER KM, et al. Differentiation of a porcine reproductive and respiratory syndrome virus vaccine strain from North American field strains by restriction fragment length polymorphism analysis of ORF5[J]. Journal of Veterinary Diagnostic Investigation, 1998, 10(2):140-144. [14] 张洪亮, 张文立, 相丽润, 等. 2017年我国输入性北美1-7-4分支PRRSV的基因组序列分析[J]. 中国预防兽医学报, 2018, 40(10):875-879. ZHANG HL, ZHANG WL, XIANG LR, et al. The genomic analysis of imported North America 1-7-4 porcine reproductive and respiratory syndrome virus in China in 2017[J]. Chinese Journal of Preventive Veterinary Medicine, 2018, 40(10):875-879. [15] XIE CZ, HA Z, NAN FL, et al. Characterization of porcine reproductive and respiratory syndrome virus (ORF5 RFLP 1-7-4 viruses) in northern China[J]. Microbial Pathogenesis, 2020, 140. doi: 10.1016/j.micpath.2019.103941. [16] XIE CZ,TAO YM, HA Z, et al. Characterization of a new NSP2-deletion NADC34-Like Porcine Reproductive and Respiratory Syndrome Virus in China[J]. Research in Veterinary Science, 2022, 152:212-218. [17] XU H, SONG S, ZHAO J, et al. A potential endemic strain in China: NADC34-like porcine reproductive and respiratory syndrome virus[J]. Transboundary and Emerging Diseases, 2020, 67:1730-1738. [18] 李文忠, 荣新利, 刘野, 等. 天津地区猪繁殖与呼吸综合征流行毒株ORF5基因的克隆及遗传变异分析[J/OL]. 中国动物传染病学报,1-10[2023-06-09]. https://doi.org/10.19958/j.cnki.cn31-2031/s.20230210.003. LI WZ, RONG XL, LIU Y, et al. Cloning and genetic variation analysis of ORF5 gene of porcine reproductive and respiratory syndrome epidemic strains in Tianjin[J/OL]. Chinese Journal of Animal Infectious Diseases,1-10[2023-06-09]. https://doi.org/10.19958/j.cnki.cn31-2031/s.20230210.003. [19] 许浒, 龚帮俊, 李超, 等. 中国新发L1A PRRSV变异株的出现与流行[J]. 中国预防兽医学报, 2023, 45(8):779-786. XU H, GONG BJ, LI C, et al. Analysis of the emergence and epidemic status of new L1A PRRSV variants in China[J]. Chinese Journal of Preventive Veterinary Medicine, 2023, 45(8):779-786. [20] LI P, SHEN Y, WANG T, et al. Epidemiological survey of PRRS and genetic variation analysis of the ORF5 gene in Shandong province,2020 to 2021[J]. Frontiers in Veterinary Science, 2022, 9. doi: 10.3389/FVETS.2022.987667. [21] ZHU Z, YUAN L, HU D, et al. Isolation and genomic characterization of a Chinese NADC34-like PRRSV isolated from Jiangsu province[J]. Transboundary and Emerging Diseases, 2022, 69(4):1015-1027. [22] 何晓明, 王东东, 田小艳, 等. 2019—2021年我国部分地区PRRSV ORF5基因遗传变异分析[J]. 中国动物检疫, 2023, 40(2):9-16. HE XM, WANG DD, TIAN XY, et al. Genetic variation analysis on ORF5 gene of PRRSV in China[J]. China Animal Health Inspection, 2023, 40(2):9-16. [23] 蒋智勇, 楚品品, 陈天宝, 等. 广东省猪繁殖与呼吸综合征病毒ORF5基因遗传变异分析[J]. 广东农业科学, 2022, 49(4):97-105. JIANG ZY, CHU PP, CHEN TB, et al. Genetic variation analysis of ORF5 genes of porcine reproductive and respiratory syndrome virus in Guangdong province[J]. Guangdong Agricultural Sciences, 2022, 49(4):97-105. [24] ZHAO J, XU Z, XU T, et al. Molecular characterization of the Nsp2 and ORF5s of PRRSV strains in Sichuan China during 2012-2020[J]. Animals, 2022, 12(23). doi: 10.3390/ANI12233309. [25] ZHOU L, YU JF, ZHOU J, et al. A novel NADC34-like porcine reproductive and respiratory syndrome virus 2 with complex genome recombination is highly pathogenic to piglets[J]. Infection, Genetics and Evolution, 2023, 112. doi: 10.1016/J.MEEGID.2023.105436. [26] XU H, LI C, LI W, et al. Novel characteristics of Chinese NADC34-like PRRSV during 2020–2021[J]. Transboundary and Emerging Diseases, 2022, 69(5):3215-3224. [27] BAO HY, LI XD. Emergence and spread of NADC34-like PRRSV in China[J]. Transboundary and Emerging Diseases, 2021, 68(6):3005-3008. [28] SONG SJ, XU H, ZHAO J, et al. Pathogenicity of NADC34-like PRRSV HLJDZD32-1901 isolated in China[J]. Veterinary Microbiology, 2020, 246. doi: 10.1016/j.vetmic.2020.108727. [29] YUAN LL, ZHU ZB, FAN J, et al. High pathogenicity of a Chinese NADC34-like PRRSV on pigs[J]. Microbiology Spectrum, 2022, 10(4). doi: 10.1128/SPECTRUM.01541-22. [30] SUN YF, LIU Y, YANG J, et al. Recombination between NADC34-like and QYYZ-like strain of porcine reproductive and respiratory syndrome virus with high pathogenicity for piglets in China[J]. Transboundary and Emerging Diseases, 2022, 69(5):3202-3207. [31] WU Y, PENG OY, XU QP, et al. Characterization and pathogenicity of two novel PRRSVs recombined by NADC30-like and NADC34-like strains in China[J]. Viruses, 2022, 14(10):2174.
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