摘要： 通过对我国地方猪种与国外猪种比较，筛选与生长发育性状相关的差异候选基因，探索猪种之间生长发育差异的分子机制。分别选择5头内江猪和大约克夏猪进行全基因组重测序，以10 kb滑动窗口和1 kb步长计算群体间遗传分化指数（Fst）平均值，并依据Fst筛选差异SNPs。最终在内江猪与大约克夏猪的比较中分别鉴定出48 924个非同义SNP，它们高度影响2 490个基因。同时，在乙酰辅酶A乙酰转移酶1（ACAT1）、胰岛素样生长因子受体2（IGF2R）和胰岛素样生长因子2 mRNA结合蛋白3（IGF2BP3）基因中检测到3个非同义SNP，这可能影响乙酰辅酶A向乙酰乙酰辅酶A的转化和胰岛素信号通路的正常功能。本研究结果将为探索决定猪表型特征的遗传差异提供基础信息。
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CN 11-5435/S
主管：中华人民共和国农业农村部
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CN 11-5435/S
主管：中华人民共和国农业农村部
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