Abstract: Antibiotic resistance made bacterial infections in pig farming difficult to treat, caused significant economic losses to the pig farming industry. Currently, bacterial resistance in pigs showed trends of multidrug and broad-spectrum resistance, primarily achieved through inactivating enzymes and modifying enzymes, altering targets, reducing permeability, active efflux, and forming biofilms. Additionally, under antibiotic pressure, resistant bacteria continuously produce a wide variety of resistance genes, which could be transferred to other pathogens through genetic transfer. In the pig farming industry, it was urgent to establish a comprehensive bacterial resistance control system to curb the cross-species spread of resistance genes through technological breakthroughs and policy guidance. This article would provide an in-depth analysis of the current status of bacterial resistance in Chinese pig farming, focus on the types of resistant bacteria, their resistance status, mechanisms of generation, and control measures, aim to provide scientific evidence for the clinical treatment and precise prevention of resistant bacteria.

Key words: pig; disease; bacterial disease; antibiotic; drug resistance; resistance mechanism; prevention and control strategy